Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy
Identifieur interne : 000E72 ( Main/Exploration ); précédent : 000E71; suivant : 000E73Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy
Auteurs : Marie Kostine ; Marie-Elise Truchetet ; Thierry SchaeverbekeSource :
- Rheumatology (Oxford, England) [ 1462-0324 ] ; 2019.
Abstract
Compared with conventional cancer therapies, the spectrum of toxicities observed with checkpoint inhibitors is unique and can affect any organ system. Arthralgia and myalgia were by far the most commonly reported rheumatic immune-related adverse events in clinical trials, and there is now a growing number of case series and reports describing clinical features of
Url:
DOI: 10.1093/rheumatology/kez295
PubMed: 31816082
PubMed Central: 6900916
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy</title><author><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author><author><name sortKey="Truchetet, Marie Elise" sort="Truchetet, Marie Elise" uniqKey="Truchetet M" first="Marie-Elise" last="Truchetet">Marie-Elise Truchetet</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author><author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31816082</idno><idno type="pmc">6900916</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900916</idno><idno type="RBID">PMC:6900916</idno><idno type="doi">10.1093/rheumatology/kez295</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000D83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D83</idno><idno type="wicri:Area/Pmc/Curation">000D83</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D83</idno><idno type="wicri:Area/Pmc/Checkpoint">000A50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A50</idno><idno type="wicri:Area/Ncbi/Merge">002659</idno><idno type="wicri:Area/Ncbi/Curation">002659</idno><idno type="wicri:Area/Ncbi/Checkpoint">002659</idno><idno type="wicri:doubleKey">1462-0324:2019:Kostine M:clinical:characteristics:of</idno><idno type="wicri:Area/Main/Merge">000E72</idno><idno type="wicri:Area/Main/Curation">000E72</idno><idno type="wicri:Area/Main/Exploration">000E72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clinical characteristics of rheumatic syndromes associated with checkpoint inhibitors therapy</title><author><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author><author><name sortKey="Truchetet, Marie Elise" sort="Truchetet, Marie Elise" uniqKey="Truchetet M" first="Marie-Elise" last="Truchetet">Marie-Elise Truchetet</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author><author><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><affiliation><nlm:aff id="kez295-aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Rheumatology (Oxford, England)</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Compared with conventional cancer therapies, the spectrum of toxicities observed with checkpoint inhibitors is unique and can affect any organ system. Arthralgia and myalgia were by far the most commonly reported rheumatic immune-related adverse events in clinical trials, and there is now a growing number of case series and reports describing clinical features of <italic>de novo</italic> rheumatic immune-related adverse events, which will be the focus of this review. Some patients develop genuine classic rheumatic and musculoskeletal diseases, but a number of rheumatic immune-related adverse events mimic rheumatic and musculoskeletal diseases with atypical features, mainly polymyalgia rheumatica, rheumatoid arthritis and myositis, as well as several systemic conditions, including sicca syndrome, vasculitis, sarcoidosis, systemic sclerosis and lupus.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wei, Sc" uniqKey="Wei S">SC Wei</name></author><author><name sortKey="Duffy, Cr" uniqKey="Duffy C">CR Duffy</name></author><author><name sortKey="Allison, Jp" uniqKey="Allison J">JP. 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Meyaard</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name><name sortKey="Schaeverbeke, Thierry" sort="Schaeverbeke, Thierry" uniqKey="Schaeverbeke T" first="Thierry" last="Schaeverbeke">Thierry Schaeverbeke</name><name sortKey="Truchetet, Marie Elise" sort="Truchetet, Marie Elise" uniqKey="Truchetet M" first="Marie-Elise" last="Truchetet">Marie-Elise Truchetet</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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